Macrophage Phenotype’s Modulation by Cell Shape: Biological & Biomedical Sciences Other

Macrophage Phenotype’s Modulation by Cell Shape
Student’s Name
Institutional Affiliation

Macrophage Phenotype’s Modulation by Cell Shape
Premise
The scientific background for the article “Modulation of Macrophage Phenotype by Cell Shape” is macrophage phenotypic polarization, which is regulated by the soluble factors present in the microenvironment. The paper covers this scientific background appropriately by describing the importance of macrophages’ changes in cell shape and their essential functionalities.
Advance
The article seeks to reveal the role of cell elongation when macrophage phenotype polarization is regulated. Although it is well-known that macrophages can adopt distinctive geometrics, less is known about the role or functionality of cell shape alterations (McWhorter, Wang, Nguyen, Chung, & Liu, 2013). As such, researchers used micropatterning strategy to regulate the cell shape of macrophages to demonstrate cell elongation.
Hypothesis
The paper has a specific, testable, and well-defined research question, which is ideally high impact. The question is: How do alterations of macrophage cell shape offer integral cues on the modulation of its phenotype polarization (McWhorter et al., 2013)?
Technology
The article demonstrates a new capability that shows how the changes of macrophage cell shape are associa...