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Health, Medicine, Nursing
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Case Study
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GI Peptic Ulcer Case Study #2

Case Study Instructions:

GI-Peptic Ulcer Case Study Peptic ulcers are a common disease affecting approximately 12% of Americans. The causes range from bacteria, to tumors, diet, and medication reactions. Read the following case study on Gastrointestinal (GI) disorders. While reading, reflect on your own knowledge of the pathopharmacology along with the role of a nurse as an in-field teacher. Mr. P is a 48-year-old businessman who went to the ER at 4 a.m. with complaints of burning epigastric pain that woke him from a sound sleep. He had experienced nighttime pain like this before and it had resolved with TUMS, but since watching a show on television, this time he was afraid he was having a heart attack and woke his wife to drive him to the ER. Upon arrival, the workup revealed negative for MI, and the ER physician transferred him to the urgent care unit adjacent to the ER for an H. Pylori test (positive) and an endoscopy that revealed a gastric ulcer. The physician orders amoxicillin (Amoxil) 1g every 12 hours for 14 days, clarithromycin (Biaxin) 500mg every 12 hours for 14 days, and lansoprazole (Prevacid) 30mg every 12 hours for 14 days, with orders to follow up with his primary care provider. You note a moderately overweight man whose clothes smell vaguely of tobacco. You are the nurse responsible for discharging Mr. P. Based on the case study, write a 3 pages paper responding to the following:  

Describe the differences in mechanism of action between Histamine-2 antagonists, antacids, and proton pump inhibitors.

What adverse effects should Mr. P. be aware of while taking these prescribed medications?

Acids in the GI tract serve a valuable purpose in food digestion and maintenance of overall health. Drugs that prohibit the secretion of this acid have been shown to leave patients at higher risk for what ailment? What additional teaching will be required prior to Mr. P's discharge? Refer to the "GI-Peptic Ulcer Application Rubric" prior to submission. 200–180 Points (Exemplary) Paper or writing assignment exceeds the requirements and exceeds academic writing expectations. Each response:

Explains in detail the differences and commonalities in mechanism of action between Histamine-2 antagonists, antacids, and proton pump inhibitors • Describes multiple adverse effects the patient should be aware of while taking the prescribed medications in the case study

 Identifies the ailment and contributing factors associated with this case study’s drugs

Explains in detail additional teaching that will be required prior to the patient’s discharge

Demonstrates thorough reflection of knowledge of the pathopharmacology along with the role of a nurse as an in-field teacher • Meets the minimum required page length: 2–3 pages

Meets the requirements of the Application instructions and is submitted by the due date

Is substantive, reflective, and evidence based

Uses language that is appropriate, and generally clear and concise

Has few errors in spelling, grammar, and syntax Required: Resources: Course Text: Karch, A. M. (2013). Focus on Nursing Pharmacology (6th ed.). Philadelphia, PA: Lippincott Williams & Wilkins Chapter 57, "Drugs Affecting Gastrointestinal Secretions" Gastrointestinal (GI) disorders are commonly found problems in health care. Different GI secretion disorders and the different drugs used to treat these disorders are examined in this chapter. Chapter 58, "Drugs Affecting Gastrointestinal Motility" In this chapter, GI disorders related to the motor activity of the system are discussed. The different drugs used to stimulate, lubricate, and block GI movement are also discussed. P.S: PUBLICATION OF ALL REFERENCES NEED TO BE 5 YEARS OR LESS

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GI Peptic Ulcer Case Study
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GI Peptic Ulcer Case Study
Mechanisms of action
Histamine-2 antagonists, antacids, and proton pump inhibitors have different mechanisms of actions. Histamine-2 antagonist: this drug acts by binding histamine type two receptors on the antiluminal/basolateral surface of gastric parietal cells, obstructing the pathways of gastric acid secretion and production (WebMD, 2014). The selectivity of histamine-2 antagonists is important since it has little or no effect on the histamine type 1 receptors. H2-antagonists are basically competitive inhibitors of histamine at the H2 receptor, therefore inhibiting gastrin-stimulated acid emission and proportionately decreasing the volume of gastric juice. Moreover, histamine-mediated secretion of pepsin is reduced. These medications are well absorbed from the gastrointestinal tract, with onset of action 30 minutes to 1 hour after ingestion and peak effects at one hour to two hours (WebMD, 2014).
Antacids: these drugs act by neutralizing gastric acid and reducing pepsin activity. Additionally, some antacids absorb pepsin. These agents relieve symptoms, promote the healing of ulcers, and decrease recurrence (Evangelista, 2011). Antacids include magnesium carbonate, magnesium hydroxide, calcium carbonate, and aluminum hydroxide. They make the juices in the stomach less acidic (WebMD, 2014). Proton pump inhibitors: According to Merck Manual (2014), these medications are strong inhibitors of H+, K+ -ATPase. A proton pump inhibitor basically acts through irreversible inhibition of the H+/K+ ATPase, within the stomach’s parietal cells. It inhibits the secretion of gastric acid and a lengthy period of action. Proton pump inhibitors decrease appreciably the quantity of acid which the stomach produces that in turn decreases irritation of the stomach lining and allow ulcers to heal (Evangelista, 2011). These medications are referred to as proton pump inhibitors since they usually work by inhibiting or blocking a chemical system known as hydrogen-potassium adenosine triphosphatase enzyme or simply proton pump. The proton pump is located in the stomach’s lining which produce the stomach acid (Abraham, 2012).
Adverse effects
There are several adverse effects which Mr. P needs to be aware of as he takes these prescribed drugs. Antacids have the potential of interfering with the absorption of other medicines such as iron, digoxin, and tetracycline. Generally, the common side effects of antacids are as follows: stomach cramps, flatulence, diarrhea, constipation, as well as vomiting or feeling sick (Evangelista, 2011). The adverse effects of histamine 2 antagonists are not common. They are minor and often consist of diarrhea, muscle aches, headache, drowsiness, and fatigue (WebMD, 2014). Moreover, hallucination, depression and confusion have also been reported, and therefore Mr. P needs to be aware of these adverse effects. High dosages of these drugs taken over an extended time period have resulted in sexual dysfunction as well as breast enlargement in men; hence Mr. P shou...
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